Xplain Data Research on Pressure Injuries Accepted for ISPOR 2026

Xplain Data, together with academic partners from the United States, will present new research at ISPOR 2026 in Philadelphia.

The project,
“Object-Centric Causal Discovery in MIMIC-IV: A Paradigm Shift for Identifying Risk Factors for Hospital-Acquired Pressure Injuries in Real-World Clinical Data,”
has been accepted as a poster presentation.

The work was developed in collaboration with Andy Wilson (University of Utah), an expert in real-world data and causal inference, and Dr. Jenny Alderden (Boise State University), a specialist in pressure injuries and board member of the National Pressure Injury Advisory Panel (NPIAP).

Background

Hospital-acquired pressure injuries (HAPIs) remain a significant challenge in healthcare. Approximately 2.5 million patients in the U.S. are affected each year. They occur in 6–10% of surgical critical care patients, with a global prevalence of around 8.4%.

The economic impact is substantial, with total annual costs in the U.S. estimated between $9.1 billion and $26.8 billion, and per-patient costs ranging from $20,900 to $151,700, depending on severity.

Approach

The project applies an object-centric approach to Causal Discovery using the MIMIC-IV clinical database. This method is designed to better capture relationships between clinical entities compared to traditional tabular models, with the goal of identifying more reliable risk factors in real-world clinical data.